Center for Research and Innovation in Biodiversity and Drug Discovery
Scientists at a FAPESP-funded research center investigated the mechanism that produces the main enzyme involved in the virus’s replication in cells. The findings are reported in the Journal of Molecular Biology.
Center for Cell-Based Therapy
A study conducted by researchers at the Center for Cell-Based Therapy in São Paulo state, Brazil, identified a genetic signature that can be used to predict whether patients should be submitted to radiation therapy.
Center for Research on Toxins, Immune-Response and Cell Signaling
In an article published in PNAS, researchers affiliated with Butantan Institute describe the genome of Bothrops jararaca and suggest the origin of genes responsible for toxins in its venom.
A group at the University of Campinas used protein mapping to show how abnormal levels of the neurotransmitter glutamate impair the functioning of neurons and oligodendrocytes. The findings could serve as a basis for more effective treatment.
Human Genome and Stem-Cell Research Center
Brazilian researchers studied the case of identical twins in which only one sibling was reinfected and developed complications after a second exposure to the virus. Their analysis showed that the adaptive immune response can be different even between individuals with the same genome.
Human Genome and Stem-Cell Research Center
A study by scientists at a FAPESP-supported research center analyzed genetic material from 86 couples in which only one spouse was infected. The results suggest that more frequent variants in the resistant spouses could lead to more efficient activation of natural killer (NK) cells, which are part of the innate immune system, the first barrier against infection.
Obesity and Comorbidities Research Center
In an article published in PLOS ONE, scientists at a FAPESP-supported research center describe the impact of hypoproteinemia on the expression of microRNAs associated with kidney development in rat embryos.
Center for Computational Engineering and Sciences
Researchers at the University of Campinas in Brazil reveal the mechanisms whereby SARS-CoV-2 disrupts the regulation of inflammation, coagulation and blood pressure when it infects alveolar cells, responsible for gas exchange in the lungs.
Center for Research, Teaching, and Innovation in Glass
A simple and affordable solution developed by researchers at the University of São Paulo and a Nigerian collaborator eliminates even multi-resistant bacteria. Clay, papaya seeds and banana peel are among the raw materials used by the group.
Center for Research on Inflammatory Diseases
A study by the University of São Paulo has discovered that when macrophages engulf cells infected by the novel coronavirus, they begin producing excessive amounts of pro-inflammatory molecules, and their capacity to recognize and phagocytize dead cells is reduced twelvefold.
Center for Research on Inflammatory Diseases
In a study of the effects of cigarette smoking on exacerbation of the disease, scientists at a FAPESP-supported research center identified a novel pathway in the inflammatory process relating to bone damage.
Brazilian Research Institute for Neuroscience and Neurotechnology
Brazilian researchers used functional magnetic resonance imaging to assess 86 volunteers who had moderate COVID-19 and compared the results with those of uninfected volunteers. Preliminary findings have not yet been published but were presented during a conference held at the University of Campinas.
Center for Research on Inflammatory Diseases
Pro-Vaccine Union, an initiative of the University of São Paulo in partnership with other organizations including Research, Innovation and Dissemination Centers funded by FAPESP, is monitoring anti-vaccine groups on Facebook in an effort to understand the workings of the social media ecosystem that spreads disinformation.
Center for Research and Development of Functional Materials
Developed at an Engineering Research Center supported by FAPESP, the novel spectroelectrochemical cell can be used to study the behavior of electrolytes and catalysts by means of X-rays and infrared or even visible light.
Center for Research and Development of Functional Materials
Researchers at São Paulo State University reused bacterial cellulose scraps usually thrown away by manufacturers of wound dressings to make strong biodegradable film for food packaging.
Brazilian Research Institute for Neuroscience and Neurotechnology
A study performed at one of the Research Centers supported by FAPESP resulted in development of a novel rehabilitation device. The article was recognized as outstanding by the 20th International Conference on Computational Science and its Applications.
Center for Research on Redox Processes in Biomedicine
An article in Cell by researchers affiliated with Harvard and the University of São Paulo shows that the metabolite succinate is released by muscle cells during physical exercise and triggers a process of tissue remodeling that makes muscles stronger and enhances metabolic efficiency.
Center for Research on Inflammatory Diseases
In defense cells from patients hospitalized with the disease, Brazilian researchers found signs of activation of a protein complex called the inflammasome, responsible for initiating the inflammatory response that can damage organs and lead to death. The findings could help identify drugs capable of interrupting the process.
Center for Cell-Based Therapy
Scientists at a research center supported by FAPESP identified a non-inherited mutation in blood cells from a patient with GATA2 deficiency that may have prevented bone marrow failure and other clinical manifestations.
