Center for Cell-Based Therapy
The initiative is coordinated by Butantan Institute and includes units in several cities accredited by Adolfo Lutz Institute (IAL), the regional reference laboratory. Short supply is the main bottleneck delaying the expansion of testing in the state.
Center for Research and Innovation in Biodiversity and Drug Discovery
Researchers at the University of Campinas are organizing professionals, supplies and equipment to test for COVID-19, understand how the virus works, identify existing drugs that are effective against the disease, and use 3D printing to produce parts for ventilators and personal protective equipment.
Center for Cell-Based Therapy
Scientists affiliated with the FAPESP-funded Center for Cell-Based Therapy have collected plasma from donors and are conducting a trial to check the safety and effectiveness of passive immunization.
Center for Research on Inflammatory Diseases
Metabolic changes associated with diseases such as pulmonary hypertension and chronic obstructive pulmonary disease may reprogram gene expression to increase production of a protein used by SARS-CoV-2 to penetrate lung cells.
Center for Metropolitan Studies
Research by the FAPESP-funded Center for Metropolitan Studies (CEM) shows that it is not feasible to separate high-risk groups in low-income communities, where the majority of the Brazilian population live. The problem is especially acute in the Southeast region, with metropolitan São Paulo displaying the largest deficit.
Obesity and Comorbidities Research Center
One of the studies will evaluate the effectiveness of drugs that inhibit bradykinin against pulmonary inflammation in critical patients. The other will analyze the transmission dynamics of the novel coronavirus in a small town in Amazonia.
Center for Research and Development of Functional Materials
Made of chitosan, a natural polymer obtained from shellfish exoskeletons, the coating enhances mechanical strength, protects against microorganisms, and prevents mass loss due to evaporation. It can also be used to coat food packaging.
Brazilian Research Institute for Neuroscience and Neurotechnology
An analysis performed with 264 people living in and around Campinas mapped 900,000 genetic markers distributed in their genomes. It aimed to lay the foundations for precision medicine and provide input for public health policy.
Center for Research in Mathematical Sciences Applied to Industry
Brazilian scientific production in mathematics has a high impact and worldwide recognition. The knowledge created in the field must now be leveraged to fuel new businesses, innovations and job creation, according to the participants in a workshop co-organized by the Center for Mathematical Sciences Applied to Industry.
Obesity and Comorbidities Research Center
The blood test method makes use of machine learning and can be used to predict whether patients will put on weight, unless they change their habits. The project was conducted in Brazil with funding from FAPESP.
Center for Research and Development of Functional Materials
Research led by a Brazilian scientist facilitates the analysis of materials comprising a large number of three-dimensionally structured atoms, such as barium molybdate, with potential applications in luminescence and organic compound degradation.
Obesity and Comorbidities Research Center
Experiments performed by Brazilian scientists showed that Zika virus inhibits tumor cell proliferation even when inactivated by high temperature. The study was supported by FAPESP and published in Scientific Reports.
Center for Research on Inflammatory Diseases
Partnering with scientists at Harvard, a group of Brazilians affiliated with the Center for Research on Inflammatory Diseases (CRID), supported by FAPESP, described the mechanisms that cause hair color loss in extreme situations.
Human Genome and Stem-Cell Research Center
Technique developed at Human Genome and Stem Cell Research Center, funded by FAPESP and hosted by the University of São Paulo, produced hepatic tissue in the laboratory in only 90 days and could become an alternative to organ transplantation in future.
Center for Research on Inflammatory Diseases
A Brazilian team at FAPESP-supported Center for Research on Inflammatory Diseases identified the strategy used by immune cells to combat the pathogen Mayaro virus, which causes symptoms similar to those of chikungunya fever. These results pave the way for the development of drugs.
Center for Research and Development of Functional Materials
Researchers at a Research, Innovation and Dissemination Center supported by FAPESP have created a composite with antifungal properties that are 32 times greater than those of silver by irradiating a metallic tungstate with electrons and femtosecond laser light.
Center for Research on Inflammatory Diseases
Phylogenomic analysis shows that pathogen isolated in Brazilian hospital does not belong to the genus Leishmania. Researchers are investigating whether this species alone can cause severe disease or intensifies symptoms in co-infected patients.
Center for Research on Redox Processes in Biomedicine
Oxide plays a key role in cardiovascular and neurodegenerative diseases as well as cancer. Experiments reveal a hitherto unknown mechanism underlying the formation of nitroso thiols.
Center for Research on Inflammatory Diseases
Using a systems biology approach, Brazilian researchers identified several genes that can be explored as therapeutic targets and as biomarkers of predisposition to chronic joint pain.
Center for Cell-Based Therapy
A study by researchers at the Center for Cell-Based Therapy, which is supported by FAPESP, identified microRNAs involved in pluripotency maintenance and cell differentiation. The discovery paves the way to the development of drugs capable of making ESCs regress to the earliest stage of development.
